Beilstein J. Nanotechnol.2019,10, 941–954, doi:10.3762/bjnano.10.95
–brain barrier using rat brain capillary endothelial cells (rBCEC4). All types of nanoparticles were taken up time-dependently by the rBCEC4cells, albeit to a different extent, causing a time- and concentration-dependent decrease in cell viability. Nanoparticle exposure did not change cell proliferation
, differentiation, nor did it induce inflammation. rBCEC4cells showed blood–brain barrier characteristics including tight junctions. None of the nanoparticles altered the expression of tight junctions or impaired the blood–brain barrier permeability. The findings suggest that effects of these nanoparticles on the
metabolic state of cells have to be further characterized before use for medical purposes.
Keywords: blood–brain barrier; laser tissue soldering; nanomedicine; nanoparticle uptake; rBCEC4cells; Introduction
Nanotechnology is commonly used in various fields, such as agriculture and pharmaceutical industry
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Figure 1:
Concentration-dependent effects of PCL- (A), PLLA- (B) and Au- (C) NPs on rBCEC4 cell viability. A ...